Dullness

Exo-PDRN Prismatic+

  • Rejuvenate
  • |
  • Plump
  • |
  • Illuminate
Youthful Vitality Serum with Prismatic PDRN & Triple Exosome Complex

Inspired by polynucleotide treatments, Exo-PDRN Prismatic+ has been expertly designed to deliver a multi-dimensional approach to visible skin health, boosting the skin’s natural rejuvenation by +50%[1].

Powered by intelligent prismatic PDRN, with a stable tetrahedral structure that mimics an arrow’s aerodynamic form, to allow for optimal penetration. Prismatic PDRN delivers 2x better skin absorption and 60% deeper skin penetration than traditional PDRN[4], to support skin recovery. The result? Next-generation rejuvenation for visibly enhanced luminosity and lasting resilience.

A highly concentrated triple exosome complex, featuring up to 151 billion exosomes per bottle, and our breakthrough GF MiniProteinTM visibly restores by supporting the skin’s natural signalling processes that facilitate skin resilience and reinforce the skin barrier. An ATP Precursor supports the skin’s natural processes involved in visible rejuvenation, for a smoother, more revitalised complexion. 

Full size (30ml)
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Medik8 Advanced Pro-Collagen+ Peptide Cream jar stands against a clean white background, with the open top revealing a rich white cream texture. Text on the jar highlights "Rejuvenating Anti-Wrinkle Moisturiser with GF MiniProtein & NAD+ Boost," while a geometric graphic in the corner reads "Growth Factor MP™ & NAD+ Longevity Booster."
Advanced Pro-Collagen+ Peptide Cream
  • Firm
  • |
  • Hydrate
  • |
  • Lift
Rejuvenating Anti-Wrinkle Moisturiser With GF MiniProteinTM & NAD+ Longevity Booster
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Sustainability

Provenance provides confidence for sustainability claims; helping to prevent 'green-washing' and empowering conscious consumers to purchase in line with their values. Provenance 'Proof Points' are all third party verified and evidenced through supply chains.

Product proof points

The Vegan Trademark

Certified to contain no animal products or byproducts and has not been tested on animals.

Partly Recyclable Packaging

Recyclable parts: Bottle (Glass), Cap (Plastic (PP)), Container (Paper) Non-recyclable parts: Pump (Mixed materials)

Brand proof points

B Corporation

Medik8 is a certified B Corporation, scoring over 80 out of 200 across Governance, Workers, Community, Environment and Customers. The certification includes a legal commitment to consider all stakeholders in decision-making. Verified every three years.

SBTi Approved Targets

Medik8 has SBTi approved science-based targets to reduce greenhouse gas emissions in line with limiting global warming to 1.5°C or well-below 2°C. Progress is reported publicly every year, with targets validated by the certifier and reviewed every 5 years.

Living Wage Employer

Medik8 is a Living Wage Employer — all staff are paid a wage calculated to meet the cost of living in the UK. Company wages are updated annually after new rates are announced by the Living Wage Foundation.

Donates to Charity

In 2022 Medik8 donated £10,000 to the National Society for the Prevention of Cruelty to Children

Carbon Measured

The footprint was calculated using GHG Protocol methodology; GWP 100.

Renewable Energy

Medik8's Innovation Centre uses electricity from 100% renewable sources.

Made in Britain

Medik8 carries the Made in Britain trademark — manufactured in the United Kingdom. Subject to facility verification and annual renewal.

Key Benefits
Visible Skin Rejuvenation

Scientifically proven to boost the skin’s natural rejuvenation by over 50%.[1] 

Refined Tone & Texture

Supports visibly smoother skin with improved tone and texture.

Optimal Skin Recovery Support

Designed to support the skin’s natural recovery processes, making it ideal for daily use and alongside professional treatments.

Restored Vitality & Luminosity

Clinically proven to improve the look of skin luminosity and vitality in 7 days.[2]

Visibly Calm, Resilient-Looking Skin

Clinically proven to improve skin barrier function in 7 days.[2]

Proven Results
Before
After
Before
After
+50% boost in natural skin rejuvenation[1]
7 days to improved skin barrier function[2]
7 days to improved skin tone[2]
7 days to improved skin luminosity[2]
7 days to visibly improved skin volume[2]
14 days to visibly improved wrinkles[2]
14 days to improved firmness[2]
100% agree this is the perfect post-procedure partner for their in-clinic PDRN treatment[3]
98% agree the results continue to get better with time[3]
[1] Proven via ex vivo study measuring Ki67 protein marker for cell proliferation vs. untreated control after 24 hours. [2] Proven via independent clinical study on Exo-PDRN Prismatic+ on 60 volunteers over 8 weeks. [3] Proven via independent consumer study conducted over 4 weeks on 52 participants who had received injectable polynucleotide treatments within a week of the study. [4] Proven via in vitro skin penetration study versus salmon and rose PDRN benchmarks. | Please Note: Product packaging shown may be different to the product received due to regional variations.
How to Use

First-time use

If you're new to Exo-PDRN Primastic+, we recommend a patch test at least 24 hours before first use. Learn how to patch test here.


How To Use

After cleansing in the morning and evening, apply 1-2 pumps of Exo-PDRN Prismatic+ evenly across the face, neck & décolletage. Use light upward strokes and allow to fully absorb.

Uses per bottle

80
Guide to Layering
Step 1: Cleanse
Medik8 Surface Radiance Cleanse tube displayed on a clean white background with a large, translucent gel texture smear. Text identifies it as a Resurfacing AHA/BHA Mangosteen Cleansing Gel in a 150mL size.
Morning
Evening
Surface Radiance Cleanse™
Select a Size
Step 2: Target
Exo-PDRN Prismatic+
Morning
Evening
Exo-PDRN Prismatic+
Full size (30ml)
Step 3: Brighten
Medik8 C-Tetra Advanced bottle displayed on a clean white background with translucent serum droplets, highlighting its lightweight gel-serum texture.
Morning
C-Tetra® Advanced
Full Size (30ml)
Step 5: Moisturise
Medik8 Advanced Pro-Collagen+ Peptide Cream jar stands against a clean white background, with the open top revealing a rich white cream texture. Text on the jar highlights
Morning
Evening
Advanced Pro-Collagen+ Peptide Cream
Select a Size
Step 5: Protect
Advanced Day Ultimate Protect™
Morning
Advanced Day Ultimate Protect™
Full Size (50ml)
Key Ingredients
Icon representing Prismatic PDRN ingredient, illustrated as a geometric triangular structure.
Prismatic PDRN

A pioneering form of vegan (contains no animal derrived ingredients) PDRN with a stable tetrahedral structure for 100% better skin absorption than traditional PDRN.[4] Composed of DNA particles that penetrate 61% deeper than traditional PDRN[4] to support skin recovery, help soothe visible irritation and reveal smoother, more youthful-looking skin.

Icon representing Triple Exosome Complex, illustrated as a cluster of small dots forming a circular pattern.
Triple Exosome Complex

Designed to support natural skin signalling processes, resilience and recovery, helping to strengthen the skin barrier and promote a healthier, more radiant-looking complexion.

Icon representing GF MiniProtein™, illustrated as a stylised folded protein structure.
GF MiniProteinTM

Visibly improves the appearance of skin structure over time by helping to boost skin’s collagen, elastin & hyaluronic acid levels.

Icon representing ATP Precursor, illustrated as a lightning bolt symbol indicating cellular energy.
ATP Precursor

An energy-carrying molecule that helps optimise the natural processes involved in visible skin rejuvenation.

Icon representing GF MiniProtein™, illustrated as a stylised folded protein structure.
GF MiniProteinTM

Visibly improves the appearance of skin structure over time by helping to boost skin’s collagen, elastin & hyaluronic acid levels.

Icon representing ATP Precursor, illustrated as a lightning bolt symbol indicating cellular energy.
ATP Precursor

An energy-carrying molecule that helps optimise the natural processes involved in visible skin rejuvenation.

Full List of Ingredients
Exo-PDRN Prismatic+
Youthful Vitality Serum with Prismatic PDRN & Triple Exosome Complex

Aqua (Water), Glycerin, Niacinamide, Lactobacillus Ferment, Centella Asiatica Leaf Extract, Lactobacillus Extracellular Vesicles, DNA, Punica Granatum Extract, Laminaria Digitata Extract, Oligopeptide-1, Disodium Adenosine Triphosphate, Sodium Hyaluronate, Lysine HCl, Proline, Histidine HCl, Arginine, Threonine, Serine, Valine, Alanine, Panthenol, Glutamic Acid, Leucine, Glycine, Taurine, Allantoin, Isoleucine, Phenylalanine, Polyacrylate Crosspolymer-6, Magnesium Aspartate, Butylene Glycol, Citric Acid, Calcium Pantothenate, Ethylhexylglycerin, 1,2-Hexanediol, Pentylene Glycol, Benzyl Alcohol, Caprylyl Glycol, Dehydroacetic Acid, Phenoxyethanol, Sodium Citrate

*Although we try our best to ensure this list of ingredients is accurate there may be product upgrades from time to time, or slight variants between different regions based on local laws, meaning the only definitive ingredient list is that which is printed on the product packaging.
  • Clinically proven
  • Fragrance-free
  • Dermatologically tested
  • Proven gentle formula
  • Certified by the vegan society
Experts Recommended

"Exo-PDRN Prismatic+ reflects our belief that visible rejuvenation comes from supporting the skin’s inherent biology. We engineered a formula that works with the natural processes skin relies on to recover and function at its best. By addressing Recover, Restore and Recharge together, we help create the optimal conditions for skin to look healthier and visibly rejuvenated."

DANIEL ISAACS
Chief Product Officer & Founding Partner of Medik8
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Find Your Serum

Reviews

Frequently Asked Questions

Can I use Exo-PDRN Prismatic+ with Crystal Retinal?

Absolutely. Exo-PDRN Prismatic+ and Crystal Retinal make an ideal age-defying duo. Crystal Retinal is our iconic nightly vitamin A serum which targets all signs of skin ageing; wrinkles, firmness, elasticity, dark spots, skin texture, and more. Exo-PDRN Prismatic+ is a twice daily lightweight serum which supports long-term skin rejuvenation and recovery. We recommend layering thinnest to thickest, where Crystal Retinal would be applied after Exo-PDRN Prismatic+.

What does skin health mean to Medik8?

At Medik8, true skin health means supporting the skin’s inherent biology. It is about building a resilient skin barrier and providing the skin with support to help it function at its peak. When your skin is healthy, visible vitality and radiance naturally follows.

Our Exo-PDRN Prismatic+ is the ultimate expression of this philosophy, utilising a 'Rejuvenation Blueprint' to recover, restore, and recharge the skin.
Through our independent clinical trials 'overall skin quality and healthy appearance' were graded. While one end of the spectrum represented skin that looks dull, lax, or unhealthy, our ultimate goal is to guide the skin all the way to the gold standard on the other end of the spectrum. In our trials, this peak profile is officially defined as 'extremely healthy, vibrant, and radiant in appearance.' The result of our clinical trials using Exo-PDRN Prismatic+ was the the product was clinically proven to improve the appearance of skin health in 7 days.[2]

Is it suitable for sensitive skin?

Yes. Exo-PDRN Prismatic+ is designed to be gentle and suitable for sensitive skin.

Can I use it with makeup?

Yes. Exo-PDRN Prismatic+ has been tested to layer seamlessly under makeup, making it ideal for everyday use.

Why are you not using spicules like other exosome serums on the market?

Spicules work by creating micro-channels through controlled micro-trauma. We chose not to include spicules as that can be unnecessarily harsh on post-treatment skin.

Instead, Exo-PDRN Prismatic+ uses a carefully engineered combination of advanced ingredients to deliver results in a gentler, more comfortable way, without placing unnecessary stress on the skin.

Can I use Exo-PDRN Prismatic+ with Liquid Peptides Advanced MP?

Absolutely. Exo-PDRN Prismatic+ and Liquid Peptides Advanced MP make an ideal age-defying duo. Use Liquid Peptides Advanced MP to target expression lines and build visible wrinkle reduction and Exo-PDRN Prismatic+ to support long-term skin rejuvenation, resilience and recovery.

Does the 'GF' in GF MiniProtein™ (found in Liquid Peptides Advanced MP, Advanced Pro-Collagen+ Peptide Cream, and Exo-PDRN Prismatic+) stand for Growth Factor?

Yes, the 'GF' on our packaging stands for Growth Factor MiniProtein™, a next-generation form of growth factor in skincare. Its small molecular size makes it more advanced than traditional options like TGF, EGF, and IGF, allowing it to unlock previously untapped cosmetic effectiveness within the skin's anti-ageing pathways.

Can I use Exo-PDRN Prismatic+ with exfoliating acids?

Yes. Exo-PDRN Prismatic+ can be applied after exfoliating acids. We recommend following with a moisturiser to help support the skin barrier and minimise the risk of any dryness.

Is Exo-PDRN Prismatic+ suitable for dry skin?

Yes. The formula contains hydrating and soothing ingredients, making it suitable for dry skin. Due to its water-light texture, we recommend following with a moisturiser for optimal comfort and results.

Is Exo-PDRN Prismatic+ suitable for oily skin?

Yes. Exo-PDRN Prismatic+ is oil-free and suitable for oily skin types. It delivers an instant healthy glow without leaving skin looking shiny.

Can I use Exo-PDRN Prismatic+ with C-Tetra Advanced?

Absolutely. Exo-PDRN Prismatic+ and C-Tetra Advanced make an ideal duo to help improve the skin’s natural recovery mechanisms. Use C-Tetra Advanced to defend against premature skin ageing and achieve accelerated visible skin brightening, and Exo-PDRN Prismatic+ to support long-term skin rejuvenation, resilience and recovery.

Should I choose Exo-PDRN or Liquid Peptides Advanced MP?

Both formulas are powerhouses and although there are slight overlaps, they focus on different skin goals. They also complement each other perfectly and can be used together in the same routine.

Choose Liquid Peptides Advanced MP if your main goal is line-smoothing. It uses dual MiniProteins™ supported by a concentrated peptide complex to specifically target expression lines and build visible wrinkle reduction over time. 

Choose Exo-PDRN Prismatic+ if your skin needs comprehensive rejuvenation and vitality. It focuses on recovery and uses next generation PDRN technology and exosomes to support the skin barrier and restore a healthy glow.

If you decide to incorporate both into your routine, we recommend layering from thinnest to thickest consistency. In this case, apply Exo-PDRN Prismatic+ first, followed by Liquid Peptides Advanced MP, both morning and evening.

Can I use Exo-PDRN Prismatic+ with exfoliating acids?

Yes. Exo-PDRN Prismatic+ can be applied after exfoliating acids. We recommend following with a moisturiser to help support the skin barrier and minimise the risk of any dryness.

Is Exo-PDRN Prismatic+ suitable for dry skin?

Yes. The formula contains hydrating and soothing ingredients, making it suitable for dry skin. Due to its water-light texture, we recommend following with a moisturiser for optimal comfort and results.

Is Exo-PDRN Prismatic+ suitable for oily skin?

Yes. Exo-PDRN Prismatic+ is oil-free and suitable for oily skin types. It delivers an instant healthy glow without leaving skin looking shiny.

Why are you not using spicules like other exosome serums on the market?

Spicules work by creating micro-channels through controlled micro-trauma. We chose not to include spicules as that can be unnecessarily harsh on post-treatment skin.

Instead, Exo-PDRN Prismatic+ uses a carefully engineered combination of advanced ingredients to deliver results in a gentler, more comfortable way, without placing unnecessary stress on the skin.

Can I use Exo-PDRN Prismatic+ with Liquid Peptides Advanced MP?

Absolutely. Exo-PDRN Prismatic+ and Liquid Peptides Advanced MP make an ideal age-defying duo. Use Liquid Peptides Advanced MP to target expression lines and build visible wrinkle reduction and Exo-PDRN Prismatic+ to support long-term skin rejuvenation, resilience and recovery.

Can I use Exo-PDRN Prismatic+ with C-Tetra Advanced?

Absolutely. Exo-PDRN Prismatic+ and C-Tetra Advanced make an ideal duo to help improve the skin’s natural recovery mechanisms. Use C-Tetra Advanced to defend against premature skin ageing and achieve accelerated visible skin brightening, and Exo-PDRN Prismatic+ to support long-term skin rejuvenation, resilience and recovery.

Should I choose Exo-PDRN or Liquid Peptides Advanced MP?

Both formulas are powerhouses and although there are slight overlaps, they focus on different skin goals. They also complement each other perfectly and can be used together in the same routine.

Choose Liquid Peptides Advanced MP if your main goal is line-smoothing. It uses dual MiniProteins™ supported by a concentrated peptide complex to specifically target expression lines and build visible wrinkle reduction over time. 

Choose Exo-PDRN Prismatic+ if your skin needs comprehensive rejuvenation and vitality. It focuses on recovery and uses next generation PDRN technology and exosomes to support the skin barrier and restore a healthy glow.

If you decide to incorporate both into your routine, we recommend layering from thinnest to thickest consistency. In this case, apply Exo-PDRN Prismatic+ first, followed by Liquid Peptides Advanced MP, both morning and evening.

Exo-PDRN Prismatic+
Full size (30ml)
Full size (30ml)